Anti-Human CD3 SAFIRE Purified CD3單抗

產(chǎn)品英文名稱：Anti-Human CD3 SAFIRE Purified

產(chǎn)品中文名稱：CD3單克隆抗體（OKT3）/抗人CD3抗體

BioGems CD3單抗特點

極低的內(nèi)毒素含量，低于0.01EU/μg蛋白 

不含疊氮鈉，適用于體內(nèi)或體外實驗

高蛋白純度

應(yīng)用

BioGems CD3單抗適用細(xì)胞：NK和NKT細(xì)胞，T細(xì)胞，Treg細(xì)胞，Th17細(xì)胞

作用機(jī)理

OKT3單克隆抗體特異性地與CD3的ε鏈/T淋巴細(xì)胞抗原受體復(fù)合物發(fā)生反應(yīng)。CD3的復(fù)合物包括 γ、 δ和ε鏈，它是TCR復(fù)合物的一部分，由成熟的T淋巴細(xì)胞和胸腺細(xì)胞譜系表達(dá)。CD3通過信號轉(zhuǎn)導(dǎo)增強(qiáng)抗原識別。而OKT3抗體是一種免疫抑制劑，在肝臟、心臟和腎臟同種異體移植排斥方面，這已被證明是一種有效的治療劑。

Description

The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.

The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.

質(zhì)量控制

BioGems CD3單克隆抗體經(jīng)過親和層析純化。

內(nèi)毒素水平：蛋白質(zhì)小于0.01 EU/µg，鱟試劑法檢測。

訂購信息  

紅榮微再代理的BioGems CD3/CD28單抗正進(jìn)行年末*活動：買二送一（四折之后），并贈送抗霾禮盒

Biogems是Peprotech的抗體品牌。CD3/CD28單抗BioGems*現(xiàn)正進(jìn)行4折*。

CD3  500ug 現(xiàn)價4130元 *(4折) 1652元

CD28  500ug 現(xiàn)價3640元 *(4折) 1456元

BioGems的SAFIRE (Sodium Azide Free Immensely Reduced Endotoxins) 類產(chǎn)品是BioGems品牌下的功能性抗體產(chǎn)品，經(jīng)特殊工藝生產(chǎn)、純化，具有諸多特點，可用于免疫細(xì)胞功能的激活、阻斷、中和研究，是腫瘤免疫研究的重要工具。

SAFIRE純化CD3單抗 (clone: OKT3)可以與TCR復(fù)合物結(jié)合，激活T細(xì)胞；SAFIRE純化CD28單抗 (clone: CD28.2)是 T細(xì)胞激活、增殖的輔助刺激分子。

紅榮微再*

CD3 CD28單抗買二送一！

在4折基礎(chǔ)上再加優(yōu)惠。

買二：CD3、CD28任選兩支。

送一：CD3、CD28任選一支。

贈送抗霾禮盒

抗霾禮盒

易可濾掛機(jī)空調(diào)伴侶防PM2.5空調(diào)過濾

易可濾防霧霾過濾PM2.5可更換式口罩

價值600多元

活動時間：2017年12月15日 - 2018年3月31日

歡迎您致電 華雅再生醫(yī)學(xué)旗艦公司：紅榮微再（上海）生物工程技術(shù)有限公司  ：1500 1904 520。紅榮微再-客服:  經(jīng)銷商專員

CD3單克隆抗體（OKT3）/抗人CD3抗體免疫細(xì)胞治療介紹：

CD3單克隆抗體（OKT3）/抗人CD3抗體是由肽鏈以非共價鍵組成的復(fù)合分子，在成熟T細(xì)胞表面表達(dá)，對阻斷急性同種異體排斥反應(yīng)起主要作用。 CD3分子與TCR組成復(fù)合受體分子，激活酪氨酸激酶，促使CD3分子免疫受體酪氨酸活化基序中的酪氨酸（Y）磷酸化。磷酸化的酪氨酸（pY）進(jìn)一步磷酸 化下游含酪氨酸的蛋白，從而引起激酶活化的級聯(lián)反應(yīng)，調(diào)控T細(xì)胞增殖和活化的靶基因，引起基因的表達(dá)和轉(zhuǎn)錄，T細(xì)胞由靜止?fàn)顟B(tài)轉(zhuǎn)為增殖和活化狀態(tài)。

CD3分子具有穩(wěn)定TCR結(jié)構(gòu)和傳遞活化信號的作用。針對CD3分子的單克隆抗體能夠激發(fā)或阻斷T細(xì)胞活化信號轉(zhuǎn)導(dǎo)，清除效應(yīng)T細(xì)胞或誘導(dǎo)調(diào)節(jié)T細(xì)胞的產(chǎn)生。

說明書

Product Information

Clone: OKT3

Format/Conjugate: SAFIRE Purified

Concentration: 2 mg/mL

Reactivity: Human

Isotype: Mouse IgG2a, kappa

Formulation: Phosphate-buffered aqueous solution, ph7.2.

Applications: FC, FA, IHC

Research Interest: Adaptive Immunity

Cell Type: NK and NKT Cells, T Cells, Treg cells, Th17 cells

Preparation & Storage:The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Application Notes

The antibody has been analyzed for quality through the flow cytometric analysis of the relevant cell type. It is recommended that the reagent be titrated for optimal performance for each application.

For Research Use Only. Not for use in diagnostic procedures

Catalog Number : 05121-25

Description

The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.

The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.

Additional Information

Clone OKT3

Format:SAFIRE Purified

Applications FC, FA, IHC

Reactivity Human

Isotype:Mouse IgG2a, kappa

Research Interest: Adaptive Immunity

Cell Type: NK and NKT Cells, T Cells, Treg cells, Th17 cells

Preperation:

The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Formulation:

Phosphate-buffered aqueous solution, ph7.2.

References:

Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York

Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.

Adair, J. R., Athwal, D. S., Bodmer, M. W., Bright, S. M., Collins, A. M., Pulito, V. L., ... & Jolliffe, L. K. (1994). Humanization of the murine anti-human CD3 monoclonal antibody OKT3. Human Antibodies, 5(1), 41-47.

歡迎您致電 華雅再生醫(yī)學(xué)旗艦公司：紅榮微再（上海）生物工程技術(shù)有限公司  ：1500 1904 520。紅榮微再-客服:  經(jīng)銷商專員